Effect of aspirin in "aspirin sensitive" patients.
نویسندگان
چکیده
منابع مشابه
Clinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease
This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...
متن کاملClinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease
This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...
متن کاملBronchial hyperreactivity to histamine in aspirin sensitive asthmatics: relationship to aspirin threshold and effect of aspirin desensitisation.
Twenty seven aspirin sensitive asthmatic patients were studied to determine the relationship between non-specific bronchial responsiveness to inhaled histamine and the degree of sensitivity to aspirin (aspirin threshold dose). No correlation was found between provocative concentration of histamine (PC20H) and aspirin threshold dose. In 11 patients the influence of aspirin desensitisation on bro...
متن کاملExpression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients.
OBJECTIVE To evaluate the expression of cyclooxygenase (COX) and lipoxygenase (LO) enzymes in nasal polyp specimens from aspirin-sensitive (AS) and aspirin-tolerant (AT) patients. DESIGN Immunohistochemical staining of archived tissue. Subjects Specimens from 26 patients (11 AS and 15 AT) with nasal polyps were analyzed; specimens from 4 patients were used as controls. INTERVENTIONS Immunoh...
متن کاملRhinosinusitis and nasal polyposis in aspirin sensitive and aspirin tolerant patients: are they different?
Hypersensitivity to aspirin (acetylsalicylic acid; ASA) is present in 5–10% of asthmatic patients and is associated with chronic rhinosinusitis and nasal polyposis, a syndrome referred to as the aspirin triad. 2 The mechanism of the hypersensitivity reaction to aspirin is not immunological, but may be related to the inhibition of cyclo-oxygenase, an enzyme responsible for prostaglandin synthesi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1984
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.288.6419.745